Overview of Picked Chemical Compounds and Intermediates
Overview of Picked Chemical Compounds and Intermediates
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1. Pharmaceutical Intermediates
Bortezomib Acid Impurity: This can be an impurity connected with bortezomib, a proteasome inhibitor Employed in the therapy of several myeloma. Its synthesis or research is crucial for making sure the purity and safety on the drug.
Abiraterone Acetate Intermediate (CAS NO. 122111-01-seven): A precursor inside the synthesis of abiraterone acetate, a drug Utilized in the remedy of prostate most cancers by inhibiting androgen manufacturing.
Imatinib Intermediate (CAS NO. 152460-10-1): A essential compound inside the synthesis of imatinib, a drug that targets particular kinds of most cancers, which includes Continual myelogenous leukemia (CML).
Docetaxel Intermediate: A compound used in the synthesis of docetaxel, a chemotherapy medication that treats several cancers for instance breast, lung, and prostate cancer.
two. Chemical Impurities and Byproducts
GeMcitabine Intermediates (T6, T9, 8): They are intermediates during the synthesis of gemcitabine, an anti-cancer drug. Their review is significant for optimizing the manufacturing system and ensuring significant purity.
Lapatinib Intermediate (CAS NO. 231278-84-five): Lapatinib is made use of trans-4-Dimethylaminocrotonic acid hydrochloride to deal with breast most cancers, and these intermediates are linked to its creation.
Fulvestrant Intermediates: Fulvestrant is an estrogen receptor antagonist Utilized in the remedy of breast most cancers. Numerous intermediates help in the synthesis of this drug.
Paclitaxel Aspect Chain Acid (CAS NO. 949023-sixteen-9): This intermediate is used in the synthesis of paclitaxel, a chemotherapy drug powerful in managing cancers such as ovarian, breast, and lung cancer.
3. Other Noteworthy Compounds
Irinotecan Hydrochloride Trihydrate (CAS NO. 136572-09-three): A chemotherapy drug Employed in the treatment of colorectal most cancers and compact cell lung most cancers.
three-Amino-1-hydroxyadamantane (CAS 702-eighty two-9): This compound is involved with the synthesis of adamantane derivatives, that have different apps, such as antiviral Qualities.
Vildagliptin Intermediates: Employed in the manufacture of vildagliptin, an oral drug for form 2 diabetes that inhibits the enzyme DPP-4 to manage blood sugar levels.
4. Miscellaneous Compounds
D-Gluconic Acid δ-Lactone (CAS NO. 61259-48-1): This compound is linked to the synthesis of various gluconic acid derivatives, that happen to be Employed in food stuff, pharmaceutical, and industrial purposes.
Canagliflozin Intermediate two: A precursor inside the synthesis of canagliflozin, a medication made use of to manage 3-dihydroisoindol-2-yl)piperidine-2 sort 2 diabetic issues by inhibiting sodium-glucose co-transporter 2 (SGLT2).